It might be about a role he really wanted but things went terribly wrong. Like he prepared for a very different type of character than what the casting team actually wanted. So, when he started acting, he could sense that he was not on the right track immediately.
One possibility is that he had a bad experience with the waiting time before the audition. Long waits can be a horror in themselves. He could have been waiting for hours, getting more and more nervous as time passed, and by the time it was his turn, he was so stressed that he couldn't perform at his best.
There could have been some unprofessional behavior from the people running the audition. For instance, they might have made inappropriate comments or had a very chaotic and disorganized setup. This would have made the whole audition experience a nightmare for Tom Holland.