They could use their ninja skills. Sasuke might use his Sharingan to find weaknesses in their captors' defenses, and Sakura could use her superhuman strength to break through any physical barriers. Maybe they work together to create a diversion and then make a run for it.
Well, if they are in a situation where they are chained or restrained, Sasuke could use his chakra to break the chains, and Sakura could use her intelligence to figure out the layout of the place they are being held. They might also find some allies among other captives. Once they have a plan, they can use their combined combat abilities to fight their way out and escape from the kidnappers.
Sakura could use her medical ninjutsu skills to create a distraction. For instance, she might make it seem like she's poisoned herself, causing Sasuke (or whoever is involved in the kidnapping) to get closer, and then she could attack and escape.
The kidnapped character could use their own hidden jutsu skills to break free. For example, if they have a teleportation jutsu they've been hiding, they could use it when Sasuke is distracted. Another way is to appeal to Sasuke's emotions. If they can remind him of his better nature or a past event that made him more empathetic, he might let them go.
Sakura would probably be initially shocked and angry. She has always cared about Sasuke, and this betrayal would hit her hard. But she is also a strong - willed ninja. So, she would quickly gather her wits and start looking for ways to escape. She might try to use her knowledge of Sasuke's fighting style against him if she gets the chance.
She could also pretend to cooperate with Orochimaru at first. Gain his trust a little bit and then when he least expects it, make her move. Maybe she could ask Orochimaru for some tools or access to certain areas under the pretense of helping him with his work, but in reality, she is setting up her escape.
Hinata could use her Byakugan to find weaknesses in Sasuke's defenses. Maybe she spots a chakra - based trap that she can manipulate to create a distraction and then make her escape. She could also use her Gentle Fist techniques in a creative way, like redirecting Sasuke's attacks back at him to create an opening for her to run.
Well, Naruto might be furious. He's always been protective of Sakura. He'd probably drop everything he's doing and go after Sasuke to rescue Sakura. Naruto has a strong sense of justice and loyalty, especially towards his friends. And Sakura is one of his closest friends, so he won't stand by and let her be in danger.
Sakura might have a hidden jutsu or power that she has not yet fully explored. In this dire situation, she could tap into this unknown ability to break free from the snakes. For example, she could have some latent chakra - based power that she discovers can repel or dissolve the snakes binding her.
Sakura might initially be very angry. She has her own strength and pride, and being kidnapped by Sasuke, someone she once cared for deeply, would be a huge blow to her self - esteem. She could try to fight back immediately, using her medical ninjutsu skills and combat training to attempt an escape.
Well, it's not really ethical. Sasuke should be more upfront and find other ways to escape rather than using Sakura like that. Sakura trusts Sasuke and for him to seduce her just for his own gain, like escaping, is wrong. Fanfiction might play with these concepts in different ways, but overall it's a behavior that doesn't sit right. It also doesn't fit well with Sasuke's character development in the original story where he is trying to become more than just a self - centered person.
She could try to appeal to Sasuke's emotions. If she can remind him of their past, of the times they fought together and cared for each other, it might make him release her. Sakura could talk about their shared experiences and how they are on the same side deep down, hoping to break through whatever is making Sasuke hold her captive.