Can you explain the reasons behind animal cloning gone wrong stories?

Answer 1

The process of nuclear transfer in cloning is also a factor. When the nucleus from a donor cell is inserted into an enucleated egg cell, there can be incompatibilities. The egg cell may not be able to fully reprogram the donor nucleus, resulting in improper development. It's like trying to fit a square peg into a round hole in some ways. The cellular machinery might not be able to handle the new genetic material in the right way, leading to malformations and health issues in the cloned animal.

Answer 2

One reason is epigenetic differences. During normal development, epigenetic marks are properly set, but in cloning, these marks may be disrupted. This can lead to abnormal gene expression, causing problems like those seen in cloned animals. For example, genes that should be turned on or off at certain times during development may not be regulated correctly.

Answer 3

Another aspect is the age of the donor cells. If the donor cells are from an older animal, they may already have accumulated some genetic damage or mutations. When these cells are used for cloning, this pre - existing damage can be passed on to the cloned offspring. Also, the in - vitro culture conditions during the cloning process can be sub - optimal. If the cells are not provided with the right nutrients and environment, it can affect their development and lead to problems in the cloned animals, as seen in the various 'animal cloning gone wrong stories'.