I think a pairing between Remus Lupin and Alcide Herveaux could be very interesting. Remus, as a werewolf in the Harry Potter world, and Alcide, a werewolf in True Blood, could share their experiences of being different from the normal humans and vampires. And then there's the pairing of Draco Malfoy and Jessica Hamby. Draco's snobbish wizard upbringing and Jessica's new - found vampirism could lead to some really tense and yet potentially character - developing interactions in a fanfiction.
Sookie Stackhouse and Hermione Granger would be an interesting pairing. Sookie has her unique abilities and comes from a world that's a bit more down - to - earth compared to the wizarding world. Hermione, on the other hand, is highly intelligent and well - versed in magic. They could learn a lot from each other, like Sookie could teach Hermione about the non - magical way of dealing with mind - reading, and Hermione could introduce Sookie to some amazing spells.
Eric Northman and Edward Cullen would be an interesting pairing. Eric is a bold and often ruthless vampire in True Blood, while Edward is more brooding and conflicted in Twilight. Their different personalities would create a lot of tension.
Hermione Granger and Rukia Kuchiki could make a great pairing. Hermione is extremely intelligent and well - versed in magic theory. Rukia, on the other hand, has a deep understanding of the spiritual world. They could collaborate on researching a strange phenomenon that is occurring between the two worlds, like a merging of certain spells and Soul Reaper techniques. Their different personalities would also create some interesting interactions, with Hermione being more outspoken and Rukia more reserved.
I think Buffy and Hermione would make an interesting pairing. Hermione's intelligence and knowledge of magic combined with Buffy's combat skills could lead to some great adventures. They could learn a lot from each other.
Hermione and Death could be an interesting pairing. Hermione is known for her intelligence and thirst for knowledge. Death, being an all - powerful entity in the Darksiders universe, could have a lot of knowledge that Hermione would be eager to learn. Their conversations would likely be deep and thought - provoking as she tries to understand the nature of death from his perspective.
Harry Potter and Lucy Pevensie would make an interesting pairing. Harry is used to being the hero in his own world, but Lucy has a unique kind of innocence and faith in Narnia. They could learn a great deal from each other. Harry could teach Lucy about more complex forms of magic, while Lucy could show Harry the power of believing without seeing, which is a big part of her relationship with Aslan.
Another great pairing would be Hermione and Bruce Banner. Hermione is extremely intelligent and book - smart, and Bruce Banner is a brilliant scientist. They could collaborate on studying the differences and similarities between magic and science. Hermione could help Bruce understand the complex theories behind magic, and Bruce could explain to Hermione some of the advanced scientific concepts he's been working on. Also, when Bruce turns into the Hulk, Hermione could use her magic to try and control or at least direct the Hulk's power in a more useful way.
Definitely Harry Potter and Spider - Man. Harry has this whole burden of being the Chosen One and having to deal with the wizarding world's problems. Spider - Man, on the other hand, is a young hero trying to balance his normal life with his superhero duties. They could bond over their shared experiences of being young and having a lot of responsibility thrust upon them.
Another interesting pairing would be Ron and Papyrus. Ron is known for his loyalty and his love for food, and Papyrus is this enthusiastic skeleton who loves cooking and making friends. They could bond over food, with Ron introducing Papyrus to some wizarding world delicacies like Butterbeer and Pumpkin Pasties, and Papyrus showing Ron his 'Spaghetti Surprise'. Their friendship could also be a source of comic relief in a more serious crossover story.
I think Ron and Prussia would make a great pair. Ron has his insecurities but also his loyalty and humor, and Prussia has his pride and bravado. They could start off not getting along, but then find common ground as they face challenges together. Also, Luna Lovegood and Japan could be an interesting combination. Luna's unique view of the world and Japan's more reserved and traditional nature could lead to some really unique conversations and adventures.