Some of the most popular crossovers in Naruto Mass Effect 2 fanfiction involve the sharing of technology and abilities. For instance, the Mass Effect's biotics could be compared or even combined with Naruto's ninjutsu. In some stories, the Asari might be interested in learning about the Uzumaki clan's sealing techniques. And then there are those fanfictions where characters like Sasuke or Sakura end up in the Mass Effect 2 universe and have to adapt to the new rules and threats there. Their ninja skills can give them an edge in some situations, but they also have to learn about things like the Reapers and the galactic politics, which makes for really engaging stories.
One popular crossover is having Naruto characters in the Mass Effect universe dealing with the Reaper threat. For example, Naruto's ninja skills could be a unique asset against the synthetic enemies. Another is Shepard learning chakra control from Naruto, which could add a new dimension to Shepard's combat abilities. And some fanfictions explore the idea of the Mass Effect races being introduced to the world of Naruto and how they interact with the ninja clans.
One popular crossover is where the technology from Star Trek is incorporated into the Mass Effect universe. For example, the warp drive from Star Trek might be used to enhance the FTL travel in Mass Effect. Another common one is having characters from both universes meet. Maybe Captain Kirk could encounter Commander Shepard. It's interesting to see how they would interact given their different leadership styles and moral compasses.
One interesting Naruto and Mass Effect crossover in fanfiction might involve Naruto characters having to adapt to the technology and different species in the Mass Effect universe. For example, Naruto's ability to quickly learn and adapt could be put to the test when faced with the complex politics and advanced weaponry in the Mass Effect galaxy.
One great crossover might involve the Ryder family from Mass Effect Andromeda somehow ending up in the Naruto universe. They could team up with Naruto and his friends to fight against a common enemy, like an ancient, powerful jutsu - created creature that threatens both the shinobi world and the new galaxy in Andromeda. The different powers and technologies from both universes would make for an interesting combination.
One interesting crossover could be with a fantasy RPG world. The Mass Effect characters might encounter magic and different races from the RPG, leading to unique storylines. For example, Shepard could learn magic spells and use them in combat alongside biotics.
In a Wolverine and Mass Effect fanfiction, there could be a story where Wolverine's memories are somehow connected to the Protheans. His long life and the mysteries surrounding his past could tie in with the ancient secrets of the Protheans in the Mass Effect world. This could lead to a search for a powerful weapon or knowledge that was lost long ago.
Shepard from Mass Effect is often a popular character. Writers might like to put Shepard in the Naruto universe and see how his or her leadership skills play out among the ninja. Also, Naruto himself is obviously a central figure and seeing his reaction to the Mass Effect elements can be really engaging.
One interesting crossover could be the integration of Mass Effect's biotic powers into Stellaris gameplay. Imagine a species in Stellaris that has the ability to manipulate mass effect fields like the biotics in Mass Effect. This would add a whole new strategic element to the game, with battles being influenced by these powerful abilities.
In a Garfield x Mass Effect fanfiction, Garfield could be given some biotic powers. Picture him using his biotics to levitate his beloved lasagna towards him instead of having to get up. Or he could use his biotic abilities to annoy Shepard by constantly moving things around on the Normandy. It would add a whole new level of humor to the Mass Effect setting.
One interesting crossover could be Iron Man's technology being introduced into the Mass Effect universe. His advanced suits could potentially give the characters in Mass Effect an edge in combat against the Reapers. For example, the repulsor technology could be adapted to create new types of biotic barriers.