Maybe an ancient dragon that has been awakened from its slumber and views Natsu as an intruder in the dragon world. Since Natsu is a new - made dragon, this old dragon might try to drive him out or even harm him.
There is a possibility that a dark mage who has been experimenting on dragons wants to capture Natsu in his dragon form. This mage could see Natsu as a valuable specimen for his evil experiments and would stop at nothing to get him.
Perhaps an evil mage who has been researching on how to control dragons. When he hears about Natsu's transformation, he sees Natsu as a perfect specimen to experiment on. So he becomes the main antagonist, trying to capture Natsu and use his powers for his own dark purposes.
It could be an evil dragon slayer who is jealous of Natsu's new form. This antagonist might try to steal Natsu's power or find a way to turn him back to his normal self out of envy.
Another option is a rival dragon slayer who sees Natsu's transformation as a threat to his own status. This rival could try to stop Natsu from fully becoming a dragon or try to defeat him to prove his own superiority.
It could be an old and powerful vampire lord who sees Natsu as a threat to his rule. Since Natsu is a new and different kind of vampire, the lord might want to eliminate him.
It could be a dark wizard who wants to capture Hedwig - as - a - dragon for her powerful new form. Maybe he wants to use her dragon abilities for his own evil plans.
The main antagonist could be an evil knight who has a vendetta against dragons. When the princess turns into a dragon, he sees her as a prime target and tries to slay her, believing all dragons are evil. He doesn't care that the princess was once human and is only focused on his own prejudiced views.
Maybe it's another dragon, a malevolent one, who sees the female dragon's act of raising a human as an abomination. He decides to target Natsu to prove a point or to gain power over the female dragon. The malevolent dragon could try to undermine Natsu at every turn, creating numerous challenges for him.
There might be a group of anti - magic fanatics as the main antagonists. They view Natsu's new and extremely powerful magic as a danger to the natural order of the magical world. They would try to eliminate Natsu and any other powerful mages in Fairy Tail who support him, believing that magic should be limited and controlled, not allowed to reach such overpowered levels as Natsu has.
There could be a female dragon named Ignis who is very fiery and passionate, always trying to be the closest to Natsu. Another could be a more gentle dragon named Aqua, who has water - based powers and uses her calm nature to balance out the more intense dragons in the harem.
There could be a group of pure - blood wizards who believe that dragons are beneath them and that Harry is tainting the wizarding world by associating with them. They would try to stop Harry from his dragon - related activities, and they might use underhanded tactics like casting spells on him or trying to get him expelled from Hogwarts.