A possible plot is that Spiderman gets caught in the middle of a conflict between the X - Men and a new anti - mutant organization. This organization has developed a technology that can neutralize mutant powers, but it also has a side - effect of affecting Spiderman's powers too. So, Spiderman teams up with the X - Men to take down this organization and in the process, discovers some new aspects of his own powers and the nature of mutants.
Perhaps there could be a plot where a powerful psychic entity is trying to take over the minds of both mutants and humans in New York. The X - Men sense this threat and come to the city. Spiderman initially tries to handle it on his own but soon realizes he needs help. The X - Men and Spiderman then combine their efforts. Spiderman uses his webs to physically restrain the minions of the entity while the X - Men use their powers to fight against the psychic attacks. In the end, they manage to defeat the entity and form a new alliance between mutants and non - mutants in New York.
One idea could be that the X - Men and Spiderman have to team up to stop a powerful mutant - human hybrid villain created by Oscorp. The X - Men bring their diverse powers and experience in dealing with mutants, while Spiderman adds his acrobatic skills and street - level intelligence. They start off distrusting each other, especially with some of the X - Men being wary of Spiderman as a non - mutant, but as they face challenges together, they learn to work as a team.
One idea could be that the X - Men and Spiderman team up to fight a common enemy like Magneto who has joined forces with some of Spiderman's foes, such as Doctor Octopus. They'd have to combine their powers and skills to take on this powerful alliance.
A cool plot could be that a villain creates a device that can manipulate time. This device causes chaos as it starts to merge different timelines. Spider - Man gets caught in the middle of this temporal mess while on a normal patrol in New York. He then reaches out to the Avengers for help. The Avengers, who have experience with time - related issues from previous adventures, team up with Spider - Man. Thor uses his lightning to disrupt the device's power source, while Spider - Man swings in to physically disable it with the help of Black Widow's combat skills. In the end, they manage to restore the timelines and save the day.
One possible plot could be that a new supervillain emerges who has the ability to manipulate time and space. This villain starts causing chaos in both Gotham and New York. Spiderman and Batman initially work separately to figure out what's going on. But as the situation worsens, they cross paths. Spiderman's agility and sense of humor contrast with Batman's brooding and strategic nature. They could learn from each other's fighting styles and eventually team up to defeat the villain.
A cool plot could be that the symbiote from Spiderman's world somehow gets linked to a Hive entity in the Destiny universe. This causes chaos as the combined powers create a super - powerful and evil being. Spiderman has to team up with a Warlock to find a way to separate the two and stop this new threat. The Warlock uses their knowledge of the Darkness and the Light, while Spiderman uses his physical abilities.
A possible plot could involve a mad scientist who combines the DNA of a worm with some sort of mutagen that gives it super - human like intelligence and abilities. This new 'worm - creature' starts causing chaos in the city. Spiderman, being the friendly neighborhood hero, investigates. He discovers that the worm - creature is not entirely evil but just confused. So, he tries to help it while also protecting the city from its accidental destruction.
One idea could be that Spiderman gets caught in the middle of a conflict between the X - Men and one of their powerful enemies. Maybe Magneto is causing chaos in New York and Spiderman tries to stop him on his own at first, but then realizes he needs the X - Men's help. The X - Men, in turn, are initially skeptical of Spiderman but come to respect his skills.
Definitely Wolverine and Spiderman. Wolverine's rough, no - nonsense attitude would contrast sharply with Spiderman's quippy and more light - hearted nature. Their fight scenes together would be amazing, with Wolverine's claws against Spiderman's webs. And they could also have some really interesting conversations about loyalty, as both are very loyal to their causes.
The plot might involve a genetic link between the two groups. Maybe the experiments that created the Maximum Ride characters were related to the mutant gene in some way. The X - Men could be intrigued by this and start to investigate. Along the way, they face challenges from anti - mutant and anti - Maximum Ride groups. The two teams would have to combine their forces, with Wolverine's combat skills and the flying abilities of the Maximum Ride gang being especially useful in battles against powerful foes.
One idea could be a story where Spiderman has to team up with his greatest enemies to fight a new, more powerful threat from outer space. This would force him to put aside his differences and find common ground with the likes of Doctor Octopus and Green Goblin.
One idea could be that Deadpool crashes Spiderman's homecoming dance. He shows up in his usual flamboyant style, causing chaos and hilarity. Spiderman has to try and keep Deadpool in check while also enjoying his big night. Maybe Deadpool accidentally reveals Spiderman's identity to some of the wrong people in the process.