It could start with a rift between them that becomes unbridgeable. Sasuke might side with a group that Naruto is sworn to oppose. Their ideological differences grow to such an extent that they end up in a final battle. Naruto, with a heavy heart, kills Sasuke perhaps because Sasuke refuses to back down and his actions are endangering too many lives. This would be a tragic departure from the original story where their relationship was centered around mutual understanding and redemption.
One possible motive could be a dark magic or mind - control situation. Maybe an enemy has the power to control Naruto's actions and forces him to kill Sasuke against his will. Another could be a miscommunication where Naruto believes Sasuke has done something unforgivable, like harming the village in a way that Naruto can't overlook.
One possible motive could be power. In some fanfics, Sasuke might be driven by an insatiable thirst for power and see Naruto as an obstacle. Another could be revenge, perhaps believing Naruto has wronged him in some way in that alternate story. Or it could be a matter of being corrupted by dark forces, which make him turn against Naruto.
One possible plot could be that Naruto is forced into a situation where he has no choice but to kill Haku in self - defense. Maybe Haku is under some kind of mind control and attacks Naruto relentlessly.
One possible motive could be if Sasuke goes too far in his pursuit of power and becomes a threat to the entire ninja world that even Naruto can't reason with. Maybe Sasuke starts to kill innocent people without hesitation, and Naruto, as the protector of the village and the one who believes in peace, sees no other option but to stop him by killing. Another motive could be some kind of dark magic or mind control that makes Sasuke an uncontrollable force of destruction, forcing Naruto to take drastic measures.
One possible reason could be that Sasuke might have gone too far in his pursuit of power even after the war. He could have been a threat to the newfound peace in the ninja world, and Naruto, as the protector of peace, might have felt he had no other choice.
Well, in a really dark and twisted fanfiction, Sasuke could be under some sort of mind - control spell. The spell could be so strong that it overrides his feelings for Naruto. He might then attack and kill Naruto without fully realizing what he's doing. But in the real Naruto lore, their friendship and mutual respect are so strong that this is highly unlikely.
Perhaps Fem Sasuke in this fanfiction has a different view of the world. She might believe that Naruto is a threat to her goals or to the future of the ninja world she envisions. It could also be that she has some deep - seated emotional pain that she blames Naruto for, and that leads her to kill him.
One possible reason could be a misunderstanding. Maybe Sasuke is framed for something really bad, and Naruto, in his anger and sense of justice, lashes out without knowing the truth. For example, if there's a false rumor that Sasuke has attacked the village again, Naruto might be quick to act.
Yes, there are likely some fanfics out there with such a plot. Fanfiction is a creative space where authors explore different scenarios. However, it goes against the general narrative of the Naruto series where Naruto is more about saving Sasuke.
It could be because of a dark power corrupting Sasuke. Maybe an ancient evil force takes over him and makes him see Sakura as an enemy. In some fanfics, this kind of external influence can completely change a character's actions. Also, it might be related to Sasuke's pursuit of power. If he believes Sakura is standing in the way of his ultimate power - seeking goal, he could be driven to kill her.