A new character could be created as the antagonist. For example, an Uchiha who has been corrupted by the power of the Sharingan and wants to use Naruto's special Uchiha - related abilities for his own evil purposes. This character could be jealous of Naruto's unique position within the Uchiha - related story and try to take it from him.
The Akatsuki could still be the main antagonists. Since Naruto now has Uchiha powers, they might be even more interested in him. They could see him as a threat or a valuable asset to their plans, just like they did with Sasuke.
Another option is a new, mysterious character who has a connection to an ancient evil. This character sees Sayuri Uchiha as a key to unlocking some dark power and Naruto as the one who will try to stop it. So, this character tries to either manipulate Sayuri or get rid of Naruto to achieve their evil goals.
I think Naruto and Itachi could also be main characters in this fanfic. Naruto might look up to Itachi for his self - sacrifice and powerful abilities. Itachi could act as a mentor - like figure to Naruto in the context of the fanfic, guiding him in understanding the Uchiha clan better.
Sasuke Uchiha could be a great choice as the main character. He already has a complex backstory and a lot of room for character development. His journey from seeking revenge to finding his own path in the Naruto series can be further explored in a fanfic.
It could be Orochimaru. He's always been interested in unique powers and abilities. The idea of X - 23's mutant abilities and Naruto's jinchuriki powers would be very appealing to him. He might try to capture them both to use in his experiments to gain ultimate power.
It could be a rogue ninja who has mastered parkour to an extreme level. He uses his skills to steal important ninja artifacts and Naruto has to stop him. This antagonist would be very fast and agile, making it difficult for Naruto to catch him using normal ninja techniques.
Madara could still be the main antagonist even in a 'naruto bankai fanfic'. He senses Naruto's new power and realizes it could be a threat to his plans of world domination. He adapts his strategies and attacks Naruto with all his might, trying to prevent Naruto from fully mastering and using his Bankai - inspired power to its fullest potential.
A powerful and corrupt ninja from another village could be the main antagonist. He hears about the unique knives in Naruto's village and decides to steal them to increase his own power and the dominance of his village. He would stop at nothing to get his hands on these knives, even if it means starting a war between the villages.
A mysterious figure within Konoha who has a hidden agenda. This person doesn't like the idea of Naruto breaking the norms and wearing a dress. They secretly manipulate events to make Naruto's life difficult while he's in the dress. For example, they might arrange for Naruto to be in situations where his dress - wearing causes maximum embarrassment, all in an attempt to make him conform to the traditional ways.
It could be Orochimaru. He has always been interested in the power of the dead and bringing back the strong. He might have found a way to reanimate Naruto for his own evil purposes, like using Naruto's power to take over the ninja world.