Palpatine could still be the main antagonist even if Luke turns to the dark side. He might try to use Luke as a more powerful weapon against any remaining Jedi or the Rebel Alliance. Palpatine would see Luke's newfound dark side power as a means to further his own control over the galaxy.
It could be Vader himself. Even though he's Luke's father, if he believes that Luke turning to the dark side is the only way for them to be truly united as a family, he could become the antagonist in the sense that he actively encourages Luke's descent into darkness, all while thinking it's for the best.
It could be the remaining Jedi. Since Luke is turning to the dark side, the Jedi who still uphold the light side values would be against him. They would see him as a threat to the balance they are trying to maintain and would try to stop him from fully embracing the dark side.
It could be Darth Sidious. He is always looking for powerful allies. If he senses Ahsoka's potential and her growing disillusionment with the Jedi, he might manipulate her into joining the Dark Side. His cunning and power would make him a formidable antagonist in this scenario.
It could be an existing villain from the original story who sees Adrien's potential and manipulates him into turning to the dark side. For example, a powerful sorcerer or a mastermind criminal. They could use Adrien's weaknesses, like his desire for power or his need to prove himself, against him.
It could be Sasuke. If Sasuke continues to pursue his own vendetta in a more extreme way and Naruto's attempts to bring him back fail, Sasuke could become the main antagonist. Their rivalry could turn into a full - blown battle for power and ideology, with Naruto being pushed to his limits and potentially turning dark in the process of trying to stop Sasuke.
It could be an ancient dark wizard who has been manipulating events from the shadows. This wizard might see Elsword as a powerful tool and has been slowly influencing him to turn dark. The wizard could be using dark magic to cloud Elsword's mind and make him more susceptible to negative emotions.
It could be a long - lost moon - dwelling ninja clan that has a grudge against the Leaf Village. They see Naruto as a threat to their plans on the moon's dark side.
It could be Hawk Moth. He might finally succeed in corrupting Adrien. Hawk Moth could use Adrien's inner doubts and fears to his advantage. For instance, if Adrien is worried about losing his loved ones, Hawk Moth could promise him a way to keep them safe if he joins the dark side.
Perhaps a powerful dark side cult leader. They could manipulate Ezra into believing that their way is the right one and that the dark side is a misunderstood power. The cult leader might use Ezra's own insecurities and desires to draw him into the dark side.
One possible scenario could be that Luke is lured by the power promised by a powerful dark side figure. Maybe he's faced with a situation where he believes the dark side can save someone he loves, like if Leia was in mortal danger and the only way he thought he could save her was through dark side powers.
Voldemort could still be a major antagonist, but in a different way. Since Harry is turning to the dark side, Voldemort might see him as a threat to his own power and try to eliminate him. Another could be Dumbledore. If Harry turns dark, Dumbledore would surely oppose him, trying to bring him back to the light. So Dumbledore could be an antagonist from Harry's new dark perspective.