One possible plot development could be Naruto finding strength within himself. He might start to question why his parents would do such a thing and through that self - reflection, he could begin to discover his own worth. Maybe he'll meet a mentor figure who helps him see that his parents' actions don't define him.
One possible plot development could be Naruto's struggle to break free from Orochimaru's control. He might have to face his inner demons and find new sources of power within himself. Another could be his friends trying to rescue him and having to fight against Orochimaru's minions. Maybe Naruto under Orochimaru's control is used to target the Hidden Leaf Village, creating a huge conflict.
One possible plot development could be Naruto developing new and unexpected powers as a result of the experiments. For example, he might gain the ability to use some of Madara's unique jutsu in a different way. Another could be Naruto's friends trying to rescue him and in the process learning more about Madara's true motives and the nature of the experiments. Maybe Naruto also has to struggle with his own identity as he is changed by the experiments.
One possible plot development could be Naruto's friends rallying around him. They might seek out medical help, like Sakura using her skills to stabilize him at first. Then, they could start planning revenge against Pain. Another could be Naruto having some sort of vision during his injury, perhaps about his parents or a new power he could unlock to defeat Pain in the future. And, his sensei, Kakashi, could take on a more protective role over him as he recovers.
The plot could also explore how Naruto's identity as Nagato's son affects the Akatsuki. Maybe some members of the Akatsuki would try to recruit him or use him for their own purposes. On the other hand, Naruto might try to reform the Akatsuki from within. His connection to Nagato could also lead to a different resolution of the conflict between the ninja villages. Instead of just uniting the villages as in the original story, he could aim to create a more global peace based on Nagato's broader view of the world, which was not just limited to the ninja villages.
One possible plot development could be Naruto growing up in isolation, constantly feeling the sting of being abandoned. He might develop a strong sense of self - reliance and a burning desire to prove himself to his family. Maybe he starts training secretly and becomes extremely powerful on his own. Then, when his siblings finally realize their mistake, Naruto has to decide whether to forgive them or hold a grudge.
One possible plot development could be Naruto struggling with Orochimaru's dark teachings while still holding onto his own sense of justice. Maybe he tries to find a way to use Orochimaru's knowledge for good. For example, he could learn some unique jutsu from Orochimaru and then modify them to be less harmful or more in line with Konoha's values.
One possible plot development could be Naruto initially fighting against the enslavement. He might use his ninja skills and chakra to resist the control of Rias Peerage. However, as the story progresses, he could start to understand their motives and form an unlikely alliance. For example, they might be trying to protect a greater good that Naruto didn't initially see.
Perhaps Naruto is blinded not just physically but also metaphorically by the villagers' actions. This could lead to a period of self - reflection for him. He might question his own beliefs and his desire to be accepted by the village. He could start to explore his own identity outside of the village's expectations. And as he grows in this self - discovery, he could also become a symbol of change within the village, inspiring others to look at things differently.
Another scenario might be physical abuse. His parents could be shown as using force against Naruto for minor mistakes. This would not only cause him physical pain but also make him fear his own parents. It could also lead to Naruto being more rebellious in some ways, as a form of self - defense mechanism.
One possible consequence could be that Harry becomes withdrawn and distrustful. He might have difficulty forming relationships with others, always fearing that they will also be cruel like his parents. He could also develop low self - esteem, constantly believing that he is unworthy of love and care because of how his parents treated him.