Another plot could be that Akakuro is a werewolf with a special ability, like the power to see the future. He uses this ability to try and prevent a great disaster from befalling his werewolf brethren, but in doing so, he makes some powerful enemies within the werewolf community.
A powerful vampire could be the main antagonist. Vampires and werewolves are often enemies in such fictional settings. This vampire could be after Akakuro's pack's territory or have a personal vendetta against Akakuro himself.
Maybe Thalia is turned into a werewolf instead. Percy then has to protect her from those who want to hunt werewolves. They could end up in a werewolf pack where Thalia has to learn the ways of the pack, and Percy has to earn the trust of the pack to stay with her. This could lead to a lot of internal conflict within the pack as well as between Percy and some of the pack members.
One idea could be that in a world where werewolves are more accepted, Hermione discovers Minerva was once bitten and becomes determined to help her during the full moon. She could research new spells to ease the transformation pain.
One idea could be that the werewolf futa is from a powerful werewolf clan and the girl is a human who stumbles upon their territory. The werewolf futa is initially protective of her clan but gradually falls for the girl's kind nature. Another could be a story where the girl is a witch and she uses her magic to help the werewolf futa control her more wild instincts during full moons.
One idea could be that Harry has to hide his new werewolf form from his friends at Hogwarts. He might struggle with the stigma associated with werewolves in the wizarding world, even though his friends know him well. Another could be that he discovers new magical abilities related to his werewolf form that help him in his fight against Voldemort. For example, enhanced senses that allow him to detect dark magic more easily.
One idea could be a Pokemon trainer who gets bitten by a werewolf-like Pokemon and starts to take on werewolf - like traits. They then have to struggle with controlling their new powers while still trying to compete in Pokemon battles.
One idea could be that the werewolf girlfriend has to hide her true nature from the human world but slips up during a full moon. Another could be a love triangle where a human and another supernatural being both vie for the werewolf girlfriend's affections. Or perhaps she's on a mission to protect her human lover from a rival werewolf pack.
There might be an akakuro fanfic that focuses on their daily lives in a modern AU. Akashi could be a successful businessman and Kuroko a quiet artist, and the story could explore how they meet and fall in love.
One plot idea could be Ruby discovering she has werewolf abilities during a mission. She has to learn to control it while still fighting Grimm. Another could be that in a werewolf form, Ruby has enhanced senses that help her track down a powerful and elusive enemy. Or perhaps she forms a pack with some of her friends who also get werewolf-like powers and they have to protect Vale from a new werewolf - Grimm hybrid threat.
One idea could be a Young Justice member getting bitten and turning into a werewolf and having to hide it from the team at first. Another is a werewolf - based villain that the team has to face, who has some connection to an ancient werewolf legend in the DC universe. Maybe a story where a werewolf is used as a weapon by an evil organization against the Young Justice team.