Another possibility is a dark wizard who has been secretly studying the power of the God of Lightning for years. This wizard wants the power all for himself and sees Harry as an obstacle. He could be a former Death Eater who has broken away from Voldemort's group to pursue this power on his own. He would use his knowledge of dark magic and his own minions to try and take the power from Harry.
Maybe an ancient being that was sealed away long ago but has now been awakened due to Naruto's newfound power. This being has a natural hatred for those who can control lightning and sees Naruto as a threat to its plans of taking over the ninja world. It has the ability to manipulate shadows and uses them to counter Naruto's lightning attacks.
It could be a dark wizard who also has some form of speed - related power but uses it for evil. Maybe he's jealous of Harry's newfound speed abilities and wants to steal them for himself. He would constantly be chasing Harry and trying to disrupt his life at Hogwarts.
It could be Voldemort still. Even with Harry having the power of a dragon god, Voldemort would be a major threat. He might be envious of Harry's new power and try to steal it for himself.
Perhaps a long - lost relative of the Potter family who feels they were unjustly excluded from inheriting the manor. This relative could be jealous of Harry's status and the wealth associated with the manor. They might use dark magic to try and claim what they think is rightfully theirs, leading to a battle of magic and loyalty within the Potter family and among Harry's friends.
A new dark wizard or witch could be created specifically for this fanfiction. This character could be interested in using the Huntsman's skills for their own evil purposes. If the Huntsman refuses, they become enemies. This antagonist could have powers related to dark forest magic, something that the Huntsman is familiar with but in a more malevolent form.
Voldemort could still be the main antagonist. Even if Demetri has some sort of connection or change in the fanfiction, Voldemort's overarching evil plans would still be a major threat to both Harry and Demetri, especially if Demetri tries to deviate from the Death Eaters' path.
The minotaur itself could be the main antagonist. It's a powerful and dangerous creature, and if it's been set loose in Hogwarts or is guarding something that Harry needs, it would be a major obstacle for him to overcome.
The main antagonist could be a dark wizard who has made the graveyard his lair. He uses the dark energy from the tombstones and the restless spirits there to power his dark magic. Harry stumbles upon this wizard's activities and has to stop him.
A new dark wizard or witch could be the main antagonist. This character, jealous of Harry's fame and power, creates a situation where Harry is framed for a heinous crime. They then ensure his arrest so that they can take over the role of the 'chosen one' in the eyes of the wizarding public and start spreading their own brand of dark magic.
It could be Malfoy. He might make fun of Harry for wearing a dress and try to use it to humiliate him in front of the whole school, which would then lead to a conflict between them that goes beyond the usual rivalry.