One interesting plotline could be Orochimaru trying to use Naruto for a new experiment but Naruto ends up influencing Orochimaru instead. For example, Naruto's strong will and belief in friendship might start to make Orochimaru question his own dark path.
Well, in some 'Naruto second Orochimaru fanfiction', a possible plotline is Orochimaru's redemption arc. He could start to realize the errors of his ways after seeing the destruction his actions have caused. This might lead to him trying to help the Hidden Leaf Village in some way, perhaps by sharing his vast knowledge of jutsus and forbidden techniques to fight a greater evil. Also, there could be a plotline where Orochimaru discovers a new power source that changes the power dynamics in the Naruto world.
One interesting idea could be Orochimaru seeing Naruto as a unique specimen and instead of just trying to use him, he actually starts to respect Naruto's willpower. This could lead to a strange mentorship of sorts where Orochimaru teaches Naruto some of his more unorthodox jutsu in exchange for Naruto trying to help Orochimaru find a new path that doesn't involve so much darkness.
Another plotline could be Female Orochimaru's attempts to reconcile with the Hidden Leaf. She might try to use her skills to help the village in secret at first, and then gradually gain the trust of the villagers. This would involve her interacting with Naruto and other characters in positive ways, like helping with rebuilding efforts or teaching new ninja techniques to the younger generation.
A possible plotline could be Orochimaru's redemption. He realizes the error of his ways and joins Naruto in protecting the ninja world. He could use his vast knowledge of jutsu and forbidden arts to help Naruto against new threats.
Perhaps Naruto starts to have a connection to Orochimaru's other experiments or creations. He might find himself in a situation where he has to either help or fight these other 'products' of Orochimaru's mad science. Also, the fanfiction could explore how Naruto's friends react to what has happened to him. Do they trust him still? Or are they afraid of what Orochimaru might have turned him into?
It's interesting because it allows for new storylines within the Naruto universe. For example, a female Orochimaru might have different goals or reasons for her actions compared to the male Orochimaru in the original series. This can lead to unique adventures and character growth for both Naruto and the female Orochimaru. It also gives writers a chance to explore themes like redemption and love in a different context, which can be really engaging for readers.
A plot could involve Orochimaru using his knowledge to help Naruto unlock a new power, but in the process, they get closer than expected. As they train together, their interactions become more intense and personal. Naruto's positive influence gradually changes Orochimaru's view of the world, and they end up on a journey together to face a common enemy that only their combined skills can defeat.
One plotline could be the Kyuubi teaching Naruto some ancient and powerful ninja techniques that were lost over time. Since the Kyuubi has been around for a very long time, it has a wealth of knowledge. Another could be Naruto and the Kyuubi having to team up to face a new, powerful enemy that neither of them could defeat alone.
Another idea for a fanfiction could be a time - travel story. Naruto somehow travels back in time and meets a younger Orochimaru. He tries to prevent Orochimaru from going down the dark path. This would involve Naruto using his knowledge of the future to influence Orochimaru's decisions and change the course of history in the Naruto universe.
Another fanfiction might focus on Orochimaru's early days. It could explore his relationship with his sensei, how he got interested in forbidden jutsu in the first place, and what events led him to become the villain we know. For example, perhaps he was once a curious student who was pushed too far in his thirst for knowledge.