Maybe the main antagonist is a dark sorcerer. The sorcerer's goal could be to use Hana's enslavement to Naruto to corrupt Naruto's positive energy. They might believe that by forcing this strange relationship on them, they can turn Naruto towards the dark side. So this sorcerer would constantly try to create more problems between Hana and Naruto.
Well, it could be a story where Hana is somehow magically bound to serve Naruto. Maybe she owes him a great debt and has to be his slave as a result. This could lead to various adventures where Naruto has to protect Hana while she's in this subservient role.
There's a chance that it could be a group of rogue ninjas. They want to use Anko's new position as Naruto's slave to infiltrate Konoha. They might be after some secret technique or valuable information. Naruto and Anko must work together to expose this group and save the village while also dealing with Anko's slavery situation.
Perhaps there is a group in the ninja world that believes slavery is wrong and they see Kin's situation as unacceptable. They would be the antagonists in the sense that they oppose Naruto's ownership of Kin, even if Naruto has good intentions. They might try to rescue Kin and this could lead to conflicts between them and Naruto. Also, there could be some of Kin's old allies who don't want her to be subservient to Naruto and they might cause trouble as well.
It could be Sasuke. If Sasuke has turned completely to the dark side and Naruto fails to save him, Naruto might be so frustrated and angry that it starts to make him cold - hearted towards everyone. Sasuke's actions could be the trigger for Naruto's transformation.
It could be an evil spirit that wants to use Naruto's new ghostly form for its own dark purposes. Maybe it tries to control Naruto and make him do evil things.
It could be Orochimaru. He's always been interested in dark and forbidden jutsus. He might see Naruto as an interesting experiment and use some dark magic on him to turn him into a berserker just to see what chaos he can cause in the ninja world.
It could be Sasuke. If Naruto becomes a wraith, Sasuke might see him as a threat to his own power - seeking goals. Sasuke could try to eliminate Naruto in this new form, thinking that Naruto is now too dangerous or has strayed from the path he believes in.
It could be Orochimaru. Since he has always been obsessed with immortality and power, he might see Naruto's new - found immortality as something he wants to steal or study. He could use his dark jutsus and his army of followers to try and capture Naruto.
It could be a new, powerful ninja from a far - off land who wants to destroy Konoha. This ninja might have a grudge against Naruto specifically and forces him to become the shield to protect the village.
Perhaps it's a jealous ninja from another village. This ninja has always been envious of Naruto's power. So when he gets the chance, he uses a dark magic to turn Naruto into a wolf. His goal is to make Naruto weak and lose his status among the ninja community.