Ash would be extremely devastated. Pikachu is not just his Pokémon but also his closest friend. He would likely first try to reason with Pikachu, not believing that Pikachu could truly betray him. He might be in denial for a while.
Ash could get angry. He has a strong sense of justice, and he might feel that May has violated their friendship. He could challenge her, not in a violent way, but more in a way to get an explanation and to try to make her see the error of her ways. He would likely be determined to show her that what she did was wrong.
Ash would likely be shocked at first. He's so used to seeing the good in people, especially fellow trainers. But then he'd probably get angry and determined to set things right. He has a strong sense of justice, so he wouldn't let the betrayal go unpunished.
Ash would probably be devastated. He would feel like his world has been turned upside down. At first, he might not believe it and think it's all a big mistake. As the reality sinks in, he could start to isolate himself from others, even from his Pokemon for a while. However, his strong will would eventually kick in. He would use this as motivation to become stronger, not just in his Pokemon battles but also in his ability to face challenges alone, without relying on his so - called friends.
Ash might be heartbroken at first. He'd feel a deep sense of loneliness and confusion.
Ash would probably be initially shocked. He is used to seeing the good in people and would not expect such a betrayal from Cynthia. He might stand there in disbelief for a moment, unable to process what has just happened.
I think Ash would be angry as well as hurt. He's a passionate trainer and his friends mean a great deal to him. He might challenge May in a Pokémon battle, not to defeat her but to make her see how wrong her betrayal is. And during the battle, he would keep asking her to come back to their old friendship.
Ash would be extremely hurt. He's a very loyal person, and having someone he cares about like Lillie betray him would be a huge blow. He might initially go into denial, not believing that Lillie could do such a thing.
Ash would be completely devastated. Pikachu has been his closest companion since the start of his journey. He would probably go into a state of shock at first, unable to believe that Pikachu was gone.
Ash would be heartbroken. He would probably try to talk to Pikachu first, asking it what's wrong and trying to calm it down. He might be in denial at first, thinking it's some kind of joke or that Pikachu is just playing too roughly.
Perhaps Pikachu discovers a 'dark truth' about Ash. For example, Pikachu might find out that Ash has unknowingly been involved in something that goes against Pokémon ethics, like being associated with a group that mistreats Pokémon. This discovery could make Pikachu feel betrayed by Ash first, and then Pikachu's actions would make Ash feel the same way in return.