When it comes to her relationship with other students outside of her usual circle, some might underestimate her because she's a kid. But she could surprise them with her still - sharp mind. And she might form new friendships with students who are closer to her new 'kid - age'. This could expand her social circle in ways that her older self hadn't considered, and also change the dynamics within the different houses in Hogwarts as she bridges gaps between them in her new form.
Her relationship with Harry and Ron would become more like a big brother - little sister type. They would be more nurturing towards her. For example, Ron might share his candies with her more often like he would with a little kid. Harry would be more patient when she asks a lot of questions, which she still does even as a kid but in a more innocent way.
With the teachers, they might be more lenient with her at first. Professor McGonagall, for instance, might have a soft spot for her in this state. But at the same time, they would also be worried about how to reverse the transformation. And Hermione as a kid might be more likely to approach some teachers she was a bit intimidated by before, like Snape, without that same level of fear, which could lead to some interesting interactions.
Her relationship with Ron and Harry would be strained at first. They'd feel betrayed that she left Hogwarts. But over time, they might come to understand her reasons. At Durmstrang, she'd have to build new friendships. She might befriend some students who are more interested in academic pursuits like her. Her relationship with the professors at Durmstrang would also be different. Some might be more strict and traditional, while others might see her potential and encourage her studies.
Well, one possible plot could be that the other characters in Hogwarts have to take care of her. Harry and Ron might find it really strange at first but then become very protective. They'd have to help her with simple things like tying her shoelaces or doing her homework, which she used to be so good at but now struggles with as a kid.
Their relationship with Ron would be strained at first. Ron has a pre - conceived notion about Slytherin, so he might be suspicious of Harry and Hermione. But as time goes on, he realizes that they are still the same friends and they work together to bridge the gap between Gryffindor and Slytherin.
In terms of her relationships with other Hogwarts students, some might be afraid of her and avoid her. But others, who are more open - minded, could be intrigued. For example, students from other houses might be curious about her half - vampire abilities and want to befriend her. Hermione would have to deal with a lot of mixed reactions, which would change the dynamic of her social life at Hogwarts. She might end up being closer to some students she didn't expect and more distant from those she thought were her friends.
Their relationship with Ron would be different. Instead of being in the same house, Ron would be in Gryffindor while they are in Ravenclaw. There might be a bit of an outsider feeling from Ron's side at first, but they would still be friends. However, their study and free - time activities would be more separated. For example, Ron might not be as involved in their Ravenclaw - centered projects.
Well, with his friends, they would have to adjust to his new state. Percy would rely on them a lot more. Grover might feel an even stronger need to protect him. And with other demigods, some might tease him while others would feel sorry for him. His relationship with the gods could also change. Some gods might find it amusing and not take him as seriously, while others might see it as an opportunity to manipulate him in his vulnerable state. His romantic relationship, if he had one, would be put on hold. His partner would have to wait until he's back to normal or might develop a different kind of affection, more like towards a little brother or something.
Romantically, if Hermione becomes a boy, she might attract different people. Maybe some of the female students who were just friends with her before start to have a crush on her. And she would have to figure out how to handle these new romantic interests while still being true to herself and her old friendships.
If Hermione transfers to Hogwarts, her relationships would change significantly. For starters, she would have to start from scratch building relationships with her classmates. She might befriend some students who were on the outskirts in the original story. With the teachers, she'd have to prove herself quickly. Some teachers might be more strict with her as a new transfer, while others might be intrigued by her previous magical education. Her relationship with the Gryffindor house as a whole would also be different as she tries to earn her place among them.
With Sakura, Naruto might not have the same kind of unrequited love. If he is raised by Uchiha, his values and priorities could be more in line with the Uchiha way of life. He may see Sakura more as a friend or comrade rather than having romantic feelings for her. Also, Sakura might be more intimidated by Naruto if he has Uchiha - like traits.
The relationship with his friends like Miroku and Sango would also shift. Miroku might be more careful in his interactions to avoid any misunderstandings. Sango might be more empathetic towards Inuyasha's situation. Also, any potential romantic interests that Inuyasha had in his male form could be completely turned on their head in his female form, creating a whole new dynamic.