It could be some rogue ninja clans that are after Karin for her special abilities. They might see her as a tool to gain power or information. For instance, a clan that specializes in blood - related jutsu might want to use Karin's unique blood - sensing ability for their own evil purposes.
One possible antagonist could be a rogue ninja from another village. They might target Tenten for her unique weapon - handling skills, thinking they can use her to create powerful weapons for themselves. Naruto would then have to face this ninja to save Tenten.
One potential antagonist could be a power - hungry shinobi from another village. They might view Hayate as a threat to their plans, maybe because Hayate is involved in some sort of peace - keeping mission between villages. So, they try to eliminate him. And Naruto, being the defender of his comrades, will not stand by and let that happen. There could also be a group of missing - ninjas who band together to take on Hayate, thinking he's an easy prey, but they underestimate Naruto's loyalty and strength.
Maybe some new rogue ninja group that has a vendetta against the Uzumaki family. They see Boruto as a way to strike at Naruto, so they try to harm him, which then leads to Naruto having to save him.
The obvious antagonists would be the Death Eaters. They are Voldemort's followers and are often causing trouble in the wizarding world. In this fanfiction, they might be the ones who have put Cedric in danger, either to lure Harry or for some other dark purpose.
Dark wizards or witches who are on a power - hungry spree could be the antagonists. They might see Daphne as an easy target or a way to get to Harry Potter himself. So they kidnap her to lure Harry into a trap.
In this fanfiction, it's possible that an ancient and powerful beast is the antagonist. The beast might have captured Pyraa to lure Naruto into a trap. Naruto will need to use all of his skills, including his Sage Mode if necessary, to defeat this beast and save Pyraa.
It could be some dark magic users from Lucy's world who see her as a threat. They might be trying to stop her from using her magic for good.
Well, it could be Orochimaru. He was always up to no good and had an interest in powerful ninja. He might target Naruto and Temari to either steal their powers or use them for his evil experiments, which would surely lead to them getting hurt.
Perhaps some rogue ninja from other villages. They might see Naruto as a symbol of Konoha's power and want to take him down to weaken Konoha. These rogue ninjas could be led by a powerful and vengeful shinobi who has a grudge against Konoha. So when Naruto is alone on a mission or something, they attack, and that's when Minato steps in to save him.
The Hidden Leaf Village itself could be an antagonist. If Naruto goes evil, the village that once was his home would be against him now.