The Soul Eater manga is known for its original artistic style and sometimes more complex plotlines. The anime, on the other hand, may make adjustments for visual and time constraints. For example, some minor characters might get less focus in the anime compared to the manga.
Overall, the Soul Eater manga and anime differ in terms of story arcs and character portrayals. The anime might condense or change certain storylines for better adaptation to the screen, while the manga offers more detailed and expansive world-building.