There were many anime works that had male and female leads. - "The Attacking Giant": Alan and Sanli are the male and female leads. Their relationship has experienced many twists and turns and challenges. - [Sword and Sword Arts: Kirito, Asuna, and the others are the male and female leads. They have experienced many adventures and battles in the game.] - Naruto: Naruto Uzumaki and Hinata are the male and female leads. Their relationship has experienced many trials and challenges. - One Piece: Monchi D. Luffy and Nami were the male and female leads. They experienced many adventures and battles together. - " The Blade of Ghost Destruction ": Tanjiro and Hinata Hinata are the male and female leads. Their relationship has experienced many trials and challenges. Of course, this is only a part of it. There are many other excellent anime works that also have male and female leads. You can choose according to your preferences.