This question is difficult to answer because the "most tragic" novel depends on one's personal definition and standards. However, the following novels are considered very tragic and have received widespread praise and discussion in different cultures and social backgrounds: 1."Le Misérables" was created by France's Victor Hugo. It told the story of Jean Valen, who was at the bottom of society. He experienced poverty, torture, loss of loved ones, and was finally sentenced to death. This novel is regarded as a classic in the history of world literature. It deeply probes into human nature, morality, and social issues. 2 Human Nature, from Japan, tells the story of the protagonist Ye Zang's loneliness, helplessness and confusion. He lost his family, friends and lovers in the process of growing up and finally realized the meaning of his existence and values. This novel was regarded as a classic in Japanese literature. It was widely praised for its exploration of human nature and reflection on life. 3 One Hundred Years of Solitude was written by Colombia Garcia Márquez and tells the story of a family of seven generations, covering topics such as war, revolution, love, wealth and loneliness. The protagonist, José Acualia, experienced the rise and fall of his family, the death of his loved ones, and the loneliness of his old age. This novel was considered a classic in Latino literature. These novels were widely praised and discussed in the literary world and society, but their tragic fate and profound theme made them classic works.