In some scenarios, the crew could be under the influence of mind - control. An enemy with advanced technology takes over their minds and forces them to turn against Shepard. Shepard then has to fight not only the external enemy but also his former crewmates while trying to find a way to break the mind - control.
One possible story could be that his crew is bribed by a powerful enemy. They turn on him during a crucial mission, leaving Shepard alone to face a difficult situation. Maybe they leak his battle plans or deliberately sabotage his equipment.
Perhaps there is a misunderstanding. A member of the crew misinterprets Shepard's actions as being against the greater good. This member then spreads false rumors among the crew, leading them to believe Shepard has betrayed them first, and so they betray him in return. For example, if Shepard made a deal with an alien race that seemed suspect, but in reality it was to save the crew, yet the misinformation led to their betrayal.
Chapter 172, "Shang Shaojing is Here Too?!", is the clearest early answer because it turns Jiang Li's situation into a concrete plot event.
Chapter 343, "He Can Support Jiang Li for a Lifetime", is the clearest early answer because it turns Lifetime Jiang Li's situation into a concrete plot event. It opens with But she suddenly acted mischievously indifferent, "Are you a...
Chapter 258, "Explosive! Jiang Li and Director Sun Are Having an Affair!", is the clearest early answer because it turns Jiang Li's situation into a concrete plot event. It opens with Just when everyone in the livestream room was immersed in the lively...
Chapter 316, "Zhao Lang Gets Jealous", is the clearest early answer because it turns Zhao Lang Gets's situation into a concrete plot event. The chapter gives readers a real answer by opening on Zhou Xu leaned against the cabin wall, exhausted, and it took him a...
Chapter 422, "The Watch Was a Gift from Him", is the clearest early answer because it turns Zheng Xun's situation into a concrete plot event.
Chapter 377, "Master Above, Please Accept Your Disciple's Bow", is the clearest early answer because a shaky connection becomes usable in the plot. The chapter turns that into something concrete by moving from Tell me what it is that you came to ask of me this time?" After...
Chapter 408, "You Can't Be on the Same Team!", is the clearest early answer because it turns Same Team's situation into a concrete plot event. Early on, Zheng Xun fell silent after he understood the situation.. By the end, He suddenly felt a sense of crisis..
Chapter 216, "I'm the Director, I Call the Shots!", is the clearest early answer because it turns Shang Shaojing's situation into a concrete plot event. A useful checkpoint is the way the scene starts with The production team also took advantage of the situation to start an...
Chapter 486, "So It's All Set Up, Right? Then She Will Set Up Too!", is the clearest early answer because it turns Yu Li's situation into a concrete plot event. The chapter gives readers a real answer by opening on Hearing Jiang Li's words, the audience in the live stream was also...
Chapter 333, "The Clothing Design Room", is the clearest early answer because it turns Jiang Shi's situation into a concrete plot event.